ABSTRACT
Interfollicular Hodgkin's lymphoma represents an unusual pattern of focal involvement of interfollicular zones by Hodgkin's lymphoma along with florid reactive follicular hyperplasia. It is often mistakenly diagnosed as a reactive change. We report a case of a 36 years old male with persistent lymphadenitis for three years, who was finally diagnosed as Interfollicular Hodgkin's lymphoma after being incorrectly diagnosed as reactive lymphadenitis. This case is reported in view of the unusual pattern of Hodgkin's lymphoma as well as its misdiagnosis as a benign lesion.
ABSTRACT
Objectives: Acute appendicitis is a condition characterized by inflammation of the appendix for which timely surgery is mandatory to prevent morbidity and mortality. The aim of this study was to assess the differences in incidences, age, sex and seasonal variations and to review the histological diagnoses of all the appendicectomy samples. Methods: A retrospective analysis of patients who underwent appendicectomy at the Hakeem Abdul Hameed Centenary Hospital, New Delhi during the period Jan 2007 to Oct 2010.All the relevant data were retrieved from the accompanying laboratory request forms or patients files records where available. All histology slides were also retrieved and reviewed. To overcome the lack of standardization which is inherent in a retrospective analyses of this type, on review, all the cases were grouped into histopathologic categories Results: Of the 262 cases reviewed, acute suppurative appendicitis accounted for the maximum cases(80,30.53%) and a negative appendicectomy rate of 7% was observed. Male predominance was seen with a M:F ratio of 1.4:1.A peak incidence of 35.1% was observed in the 21-30years age group. A seasonal trend of majority cases being confined to the months of June -August coinciding with the rainy season was noted. Conclusion: The vermiform appendix is a vestigial organ with no specific function. It comes into the limelight when a diagnosis of acute appendicitis is made by the surgeon based upon clinical features and physical examination. Histological examination of the appendix is therefore necessary to assess the surgeon's rate of negative appendicectomy as well as avoid missing a rare diagnosis or a malignancy.
ABSTRACT
Congenital leukemia is a rare disorder presenting in the immediate neonatal period & diagnosed at or within few days of birth.1 Because of the doubling time of leukemic cells, the disease becomes clinically evident after birth or shortly thereafter.2 Neonates with Down’s syndrome have an increased risk for congenital leukemia particularly acute megakaryoblastic leukemia (FAB M7).3 The incidence of acute megakaryoblastic leukemia in Down’s syndrome is estimated to be 400 times than in normal children.4 We present a case of congenital leukemia in a 22 day old female child with Down’s syndrome who had cyanosis and skin rashes for 2 days. Diagnosis was established on the basis of hematological investigations and cytochemistry of the cells